Chimeric T helper-B cell peptide vaccine for Japanese encephalitis virus

摘要

A vaccine composition for humans and animals against Japanese encephalitis virus infection is a composition which comprises a chimeric synthetic peptide consisting of a B cell epitope linked to a T-helper cell epitope from Japanese encephalitis proteins, wherein the chimeric peptide is in an amount sufficient to induce protective immunity against Japanese encephalitis virus infection. For example, the B cell epitope may be SEQ ID NO:46, 84 or 85; and the T-helper cell epitope may be SEQ ID NO:77, 82 or 83.