发明名称 |
Synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (BPU) sulfur analogs |
摘要 |
A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to compound 1, against cancer cell lines. 6n was more effective than compound 1 in causing apoptosis of MCF-7 cells. When compared to other drugs with a similar mechanism of action, 6n retained significant ability to inhibit tubulin assembly, with an IC50 of 2.1 muM.
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申请公布号 |
US7595326(B2) |
申请公布日期 |
2009.09.29 |
申请号 |
US20070673519 |
申请日期 |
2007.02.09 |
申请人 |
CHAMPIONS BIOTECHNOLOGY, INC. |
发明人 |
KHAN SAEED R.;HALLUR GURULINSAPPA;HIDALGO MANUEL;JIMENO ANTONIO |
分类号 |
C07D239/38;A61K31/505;A61P35/00 |
主分类号 |
C07D239/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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