发明名称 |
POLIPEPTIDO QUIMERICO FIBRINA-FILAGRINA CITRUINADO CAPAZ DE DETECTAR LOS ANTICUERPOS GENERADOS EN LA ARTRITIS REUMATOIDE |
摘要 |
The present invention concerns a chimeric polypeptide, capable of detecting the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the ± or ² chain of the fibrin and (ii) a second derived from the filaggrin. In addition, the invention comprises an antigenic composition, a method and a kit for the diagnosis of rheumatoid arthritis, from the detection of the autoantibodies generated during the course of said disease. |
申请公布号 |
ES2307421(B1) |
申请公布日期 |
2009.09.28 |
申请号 |
ES20070001167 |
申请日期 |
2007.04.30 |
申请人 |
CONSEJO SUPERIORDE INVESTIGACIONES CIENTIFICAS (CSIC);FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA |
发明人 |
HARO VILLAR ISABEL;GOMARA ELENA MA. JOSE;SANMARTI SALA RAIMON;PEREZ RODRIGUEZ MA. LUISA |
分类号 |
C07K14/75;A61K39/00;C07K14/47;G01N33/68 |
主分类号 |
C07K14/75 |
代理机构 |
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代理人 |
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地址 |
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