| 摘要 |
The disclosure relates to pharmaceutical compositions and methods of treatment comprising administering to a patient in need thereof a combination of a 2¡alkylidene-19-nor-vitamin D derivative and a bisphosphonate. Particularly disclosed is a pharmaceutical composition comprising a therapeutically effective amount of 2-methylene-19-nor-20 (S)-1alpha,25-dihydroxy vitamin D3 and a therapeutically effective amount of a biphosphonate selected from tiludronate, alendronate, zoledronate, ibandronate, risedronate, etidronate, clodronate or pamidronate for use in treating senile osteoporosis, postmenopausal osteoporosis, bone fracture, bone graft, osteopenia or male osteoporosis, in a patient receiving a low calcium diet.
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