A respiratory syncytial virus with a genomic deficiency complemented in trans

摘要

Disclosed is a virion of a pneumovirus comprising a viral genome that has a mutation in a gene coding for a G attachment protein or a fusion protein F or a mutation in both genes, said proteins being essential for infectivity of the pneumovirus, whereby the mutation causes a virus produced from only the viral genome to lack infectivity, and whereby the virion comprises the protein in a form and in an amount that is required for infectivity of the virion.