A method for conjugation of biopolymer e.g., polyalkylene glycol (PAG) to an oligonucleotide comprising combining an activated-biopolymer and an oligonucleotide in an aqueous solution at a pH at or greater than 8.5 and adding DMSO to avoid PEG side reactions and degradation.
申请公布号
WO2009073820(A3)
申请公布日期
2009.09.24
申请号
WO2008US85594
申请日期
2008.12.04
申请人
ARCHEMIX CORP.;HATALA, PAUL;BOOMER, RYAN;KURZ, MARKUS
