发明名称 |
Kinesin inhibitors as cancer therapeutics |
摘要 |
The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.
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申请公布号 |
US2009239922(A1) |
申请公布日期 |
2009.09.24 |
申请号 |
US20080313923 |
申请日期 |
2008.11.25 |
申请人 |
ABRAMS TINYA;BARSANTI PAUL;DUHL DAVID;FAURE MICHEL;RENHOWE PAUL A;WALTER ANNETTE OLGA |
发明人 |
ABRAMS TINYA;BARSANTI PAUL;DUHL DAVID;FAURE MICHEL;RENHOWE PAUL A.;WALTER ANNETTE OLGA |
分类号 |
A61K31/4174;A61P35/00;C07D233/61 |
主分类号 |
A61K31/4174 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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