METHODS AND COMPOSITIONS CAPABLE OF CAUSING POST-TRANSCRIPTIONAL SILENCING OF GENE EXPRESSION IN A SYNERGIC MANNER

摘要

The invention relates to compositions intended for post-transcriptional inhibition of gene expression through the combined use of: a modified U1 RNA directed against a pre-selected region in a target pre-mRNA-, and a siRNA-, shRNA and/or miRNA-type gene expression silencing agent, as well as to the use of said combinations for the treatment of diseases caused by the unwanted overexpression of a protein.