发明名称 |
NEW PROCESS FOR THE SYNTHESIS OF LOFERPRAMINE MALEATE: A STABLE SALT OF LOFERPRAMINE |
摘要 |
<p>This invention relates to a stable salt of Lofepramine and A process for the synthesis of stable Lofepramine maleate comprising; dissolving maleic acid in ethyl acetate by warming and the solution is then filtered hot; adding purified Lofepramine base to the said clear solution of maleic acid and heated upto about 40-60°C; filtering the precipitates of Lofepramine maleate; drying the said precipitates at 45 to 55°C to obtain Lofepramine maleate.</p> |
申请公布号 |
WO2008139484(A3) |
申请公布日期 |
2009.09.24 |
申请号 |
WO2007IN00195 |
申请日期 |
2007.05.16 |
申请人 |
R. L. FINE CHEM;RAMESHA, A., R.;ROY, A., K. |
发明人 |
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分类号 |
C07C227/42;C07C225/06 |
主分类号 |
C07C227/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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