发明名称 |
PEPTIDE-CONJUGATED OLIGONUCLEOTIDE THERAPEUTIC AND METHOD OF MAKING AND USING SAME |
摘要 |
Conjugates for the efficient delivery of sequence-specific antisense to cells of a selected type for the inhibition of a target protein have the general formula: peptide-HBL-antisense in which the peptide is a homing peptide which directs the conjugate to cells of a particular type, antisense is an antisense oligonucleotide having a sequence selected to provide sequence-specific inhibition of the target protein, and HBL is a heterobifunctional linker having reactivity towards amino and sulfhydryl groups. |
申请公布号 |
WO2009089186(A3) |
申请公布日期 |
2009.09.24 |
申请号 |
WO2009US30164 |
申请日期 |
2009.01.05 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;BENEZRA, ROBERT;HENKE, ERIK |
发明人 |
BENEZRA, ROBERT;HENKE, ERIK |
分类号 |
C07K19/00;A61P35/00 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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