THE CALCIUM SENSOR STIM1 AND THE PLATELET SOC CHANNEL ORAI1 (CRACM1) ARE ESSENTIAL FOR PATHOLOGICAL THROMBUS FORMATION

摘要

The present invention relates to a pharmaceutical composition comprising an inhibitor of stromal interaction molecule 1 (STIM1 ) or an inhibitor of STIM1 - regulated plasma membrane calcium channel activity, in particular an inhibitor of Oraii (also designated as CRACM1 ), and optionally a pharmaceutically active carrier, excipient or diluent. The invention further relates to an inhibitor of stromal interaction molecule 1 (STIM1 ) or an inhibitor of ST I M1 -regulated plasma membrane calcium channel activity, in particular an inhibitor of Orai1 (also designated as CRACM1 ), for treating and/or preventing a disorder related to venous or arterial thrombus formation.