发明名称 |
Inhibitors of nucleoside phoshorylases and nucleosidases |
摘要 |
The present invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5'-methylthioadenosine phosphorylases (MTAP), 5'-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
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申请公布号 |
US2009239885(A1) |
申请公布日期 |
2009.09.24 |
申请号 |
US20090455537 |
申请日期 |
2009.06.03 |
申请人 |
EVANS GARY BRIAN;FURNEAX RICHARD HUBERT;LENZ DIRK HENNING;SCHRAMM VERN L;TYLER PETER CHARLES;ZUBKOVA OLGA VLADIMIROVNA |
发明人 |
EVANS GARY BRIAN;FURNEAX RICHARD HUBERT;LENZ DIRK HENNING;SCHRAMM VERN L.;TYLER PETER CHARLES;ZUBKOVA OLGA VLADIMIROVNA |
分类号 |
A61K31/522;A61K31/4015;A61K31/519;A61P17/06;A61P19/02;A61P31/04;A61P33/02;A61P35/00;A61P37/02;A61P37/06;C07D207/12;C07D473/30;C07D487/04;C07H19/23 |
主分类号 |
A61K31/522 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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