发明名称 |
METHODS AND KITS FOR THE DIFFERENTIAL DIAGNOSIS OF ALZHEIMER'S DISEASE VERSUS FRONTOTEMPORAL DEMENTIA, AND FOR THE DIAGNOSIS OF FRONTOTEMPORAL DEMENTIA, COMPRISING FAS-L AND CKL 18 AS BIOMARKERS |
摘要 |
<p>The invention relates to methods and kits for the differential diagnosis of Alzheimer's disease (AD) versus frontotemporal dementia (FTD), using biomarkers TNF-a, FAS-L and CK18, taken from a biological sample. Differences in biomarker levels can be used to distinguish between AD and FTD The invention is based on a discovered correlation between FTD and markers FAS-L and CK18. Therefore the invention also relates to the diagnosis of FTD using FAS-L and CK18. The serum concentrations of these biomarkers can further be used as an index of the severity of disease, and may occur in conjunction with clinical-based diagnostic testing and neuro-imaging assessment.</p> |
申请公布号 |
WO2009114945(A1) |
申请公布日期 |
2009.09.24 |
申请号 |
WO2009CA00346 |
申请日期 |
2009.03.20 |
申请人 |
NEUMAN, MANUELA, G.;FREEDMAN, MORRIS |
发明人 |
NEUMAN, MANUELA, G.;FREEDMAN, MORRIS |
分类号 |
G01N33/68;G01N33/543;G01N33/577 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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