发明名称 |
NOVEL SIRNA STRUCTURE FOR MINIMIZING OFF-TARGET EFFECTS AND RELAXING SATURATION OF RNAI MACHINERY AND THE USE THEREOF |
摘要 |
The present invention relates to a novel siRNA structure and the use thereof. More particularly, the invention relates to a double-stranded small interfering RNA molecule (siRNA molecule) comprising a 19-21 nucleotide (nt) antisense strand and a 15-19 nt sense strand having a sequence complementary to the antisense sequence, wherein the 5 ' end of the antisense strand has a blunt end and the 3 ' end of the antisense strand has an overhang, and to a method for silencing the expression of a target gene using the siRNA molecule. |
申请公布号 |
WO2009078685(A3) |
申请公布日期 |
2009.09.17 |
申请号 |
WO2008KR07530 |
申请日期 |
2008.12.18 |
申请人 |
LEE, DONG KI;CHANG, CHAN IL |
发明人 |
LEE, DONG KI;CHANG, CHAN IL |
分类号 |
C12N15/10;C12N15/11 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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