发明名称 |
USES OF BISPECIFIC ANTIBODY COATED DENDRITIC CELLS PULSED WITH ANTIGENS AND GM-CSF IN IMMUNE REGULATION |
摘要 |
GM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, reduced T cell proliferative responses to AChR, and an expansion in the population of FoxP3+ regulatory T cells. Manipulating DCs to expand regulatory T cells is useful for the control of autoimmune diseases such as myasthenia gravis MG.
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申请公布号 |
US2009232854(A1) |
申请公布日期 |
2009.09.17 |
申请号 |
US20090401089 |
申请日期 |
2009.03.10 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS |
发明人 |
PRABHAKAR BELLUR S.;HOLTERMAN MARK J.;VASU CHENTHAMARAKSHAN;MERIGGIOLI MATTHEW N. |
分类号 |
A61K9/00;A61K35/12;A61K35/26;A61K39/00;A61K39/395;A61P37/06;C07K16/00;C07K16/28;C12N5/0784 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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