Dual specificity antibodies and methods of making and using

摘要

Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1alpha and IL-1beta and neutralize IL-1alpha and IL-1beta activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1alpha and IL-1beta) and for inhibiting the activity of the antigens, e.g., in a human subject suffering from a disorder in which IL-1alpha and/or IL-1beta activity is detrimental.