PEPTIDE NUCLEIC ACID DERIVATIVES WITH GOOD CELL PENETRATION AND AFFINITY FOR NUCLEIC ACID

摘要

A novel peptide nucleic acid (PNA) oligomer and its pharmaceutically acceptable salt are provided to ensure improved nucleic acid affinity and cell penetration and suppress or control the cell function or physiological function. A peptide nucleic acid of the chemical formula 1 or its pharmaceutically acceptable salt has excellent cell penetration and affinity to the nucleic acid. A pharmaceutical composition comprises the peptide nucleic acid derivative or its pharmaceutically acceptable salt in a therapeutically effective amount.