发明名称 |
Bispecific antibodies for inducing apoptosis of tumor and diseased cells |
摘要 |
<p>The bispecific antibodies of the present invention are in the form of a heteroconjugate that inhibits growth and induces apoptosis of a diseased cell and that does not require the recruitment of effector cells. The heteroconjugate has at least two binding arms wherein each of the binding arms possesses a different specificity and need not have apoptotic activity when not conjugated to each other. Also provided are methods of treating and diagnosing a diseased cell using the bispecfic antibodies of the present invention.</p> |
申请公布号 |
AU2004263538(B2) |
申请公布日期 |
2009.09.17 |
申请号 |
AU20040263538 |
申请日期 |
2004.08.09 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
EVA HORAK;DAVID M. GOLDENBERG;IVAN HORAK;HANS J. HANSEN;CHIEN-HSING CHANG |
分类号 |
C07K14/00;A61K39/395;C07K;C07K16/00;C07K16/28;C07K16/30;C07K16/44;C07K16/46;G01N33/574 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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