FUSION PROTEIN WITH DIRECTIONING OF VACCINAL ANTIGENS TOWARD ANTIGEN-PRESENTING CELLS AND THE APPLICATIONS THEREOF

摘要

Fusion protein that directs vaccine antigens to antigen-presenting cells, and applications thereof. The present invention relates to a gene construct that comprises, functionally linked, at least one nucleotide sequence (A) that encodes a polypeptide of SEQ ID No 1 that has a region that recognizes the ß chain of the class II DR antigen present on the antigen-presenting cell surface; and a nucleotide sequence (B) that encodes a vaccine antigen of interest. Furthermore, the present invention relates to recombinant vectors that are useful in the expression of the gene construct of the invention, transgenic cells and plants transformed or transfected with said vectors, fusion proteins encoded by the gene construct of the invention and vaccines that comprise said fusion proteins.