DETERMINANTS OF ANTIVIRAL RESPONSE

摘要

The present invention relates to antiretroviral drug susceptibility tests that can be used to identify HIV-I -infected patients whose HIV-I virus will respond to treatment with maturation inhibitors. The invention further relates to novel vectors, host cells and compositions for carrying out these novel antiviral drug susceptibility tests. This invention also relates to the screening of candidate drugs for their capacity to inhibit cleavage of the HIV-I Gag polyprotein at the CA- SPl cleavage site.