USE OF SIRNA TO ACHIEVE DOWN REGULATION OF AN ENDOGENOUS GENE IN COMBINATION WITH THE USE OF A SENSE CONSTRUCT TO ACHIEVE EXPRESSION OF A DESIRED POLYNUCLEOTIDE

摘要

The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.