POLYPEPTIDE AGENTS IN THE FORM OF CONJUGATES OF KERATIN-BINDING POLYPEPTIDES, POLYMERS, AND EFFECTOR MOLECULES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF

摘要

Disclosed are keratin-binding polypeptide agents in the form of conjugates (A'B'C') or (A'B'C'D') comprising (A') a polypeptide sequence derived from a keratin-binding polypeptide (A), and (B') a statistical average of at least one polymer chain derived from a water-soluble or water-dispersible polymer (B) that carries lateral and/or terminal reactive functional groups (b1) and is selected in such a way as to form a homogeneous aqueous solution or dispersion along with the keratin-forming polypeptide (A) to be reacted to form the conjugate (A'B'C') or (A'B'C'D') in standard conditions, the polypeptide (A) in said aqueous solution or dispersion still having a keratin-binding activity. (C') At least one linker group links the polymer chain (B') to the polypeptide sequence (A'), and (D') optionally, a statistical average of at least one effector group is linked to the polymer chain (B'). Also disclosed are a method for the production of said active polypeptide substances and the use thereof for modifying keratin and keratin-containing materials and producing cosmetic and pharmaceutical compositions.