发明名称 |
COMPOSITIONS AND METHODS FOR CONTROLLED DELIVERY OF INHIBITORY RIBONUCLEIC ACIDS |
摘要 |
Polymeric nanoparticles encapsulating inhibitory ribonucleic acids (RNAs) and methods of their manufacture and use are provided. Advantageous properties of the nanoparticles include: 1) high encapsulation efficiency of inhibitory RNAs into the nanoparticles, 2) small size of the nanoparticles that increases cell internalization, and 3) sustained release of encapsulated inhibitory RNAs by the nanoparticles that allows for administration of an effective amount of inhibitory RNAs to cells or tissues over extended periods of time. Encapsulation efficiency of inhibitory RNAs into the nanoparticles is greatly increased by complexing the inhibitory RNAs to polycations prior to encapsulation. Methods of using the polymeric nanoparticles for treating or inhibiting diseases or disorders are provided. |
申请公布号 |
WO2009114614(A2) |
申请公布日期 |
2009.09.17 |
申请号 |
WO2009US36803 |
申请日期 |
2009.03.11 |
申请人 |
YALE UNIVERSITY;SALTZMAN, W., MARK;WOODROW, KIM |
发明人 |
SALTZMAN, W., MARK;WOODROW, KIM |
分类号 |
A61K9/00;A61K9/14;A61K48/00;C12N15/11;C12N15/113;C12N15/63 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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