发明名称 |
ARCHAEOSOMES AS ADJUVANTS AND CARRIERS FOR ACELLULAR VACCINES TO INDUCE CYTOTOXIC T LYMPHOCYTE (CTL) RESPONSES |
摘要 |
<p>The invention provides methods and compositions useful for inducing major histocompatibility complex class-I (MHC-I)-restricted cytotoxic T lymphocyte (CTL) response in a mammalian host immunized with acellular (non-replicating) antigen. The methods comprise using a liposome, an archaeosome, comprising a polar lipid extract of an archaeobacterium as both immune modulator and carrier for the non-replicating antigen. In addition to a strong antigen-specific CTL response, the archaeosome adjuvant elicits CD4<+> Th1, CD4<+> Th2 (antibody), and memory responses to the acellular antigen in the vaccine composition. The invention provides methods for mounting a rapid, and a long lasting protective immunity in the vaccinated host against infections caused by intracellular pathogens, especially those that require the host to mount an antigen-specific CD8<+> T cell immune response for the protection. The methods of the invention are also useful in, but not restricted to, vaccines for preventing or reducing growth of solid tumors.</p> |
申请公布号 |
EP1223978(B9) |
申请公布日期 |
2009.09.16 |
申请号 |
EP20000967482 |
申请日期 |
2000.10.12 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
SPROTT, G., DENNIS;KRISHNAN, LAKSHMI;CONLAN, J., WAYNE;PATEL, GIRISHCHANDRA, B.;WILLICK, GORDON E. |
分类号 |
A61K9/127;A61K39/39;A61K38/00;A61K38/21;A61K38/22;A61K39/00;A61K39/002;A61K39/02;A61K39/12;A61K47/14;A61K47/24;A61K47/46;A61P31/00;A61P31/04;A61P31/12;A61P35/00;A61P37/04 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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