发明名称 |
METHOD FOR IDENTIFYING TFF2 REGULATING AGENTS |
摘要 |
<p>Agents useful for modulating the dioxin/aryl hydrocarbon receptor (AhR) can now be identified by determining the binding to said receptor and whether said agent suppresses or inhibits the expression of a gene substantially consisting of a sequence according to one of SEQ. ID. NO. 1 and SEQ. ID. NO. 2; a nucleotide sequence functionally homologous, or substantially homologous, or at least 90% identical to one of SEQ. ID. NO. 1 and SEQ. ID. NO. 2; and a nucleotide sequence complementary to the nucleotide sequence of SEQ. ID. NO. 1 or SEQ. ID. NO. 2. Such agents find utility in pharmaceutical compositions and methods for the prevention, alleviation or treatment of diseases involving gastrointestinal hyperplasia, such as gastrointestinal cancer or gastric cancer.</p> |
申请公布号 |
EP1625395(B1) |
申请公布日期 |
2009.09.16 |
申请号 |
EP20040732864 |
申请日期 |
2004.05.13 |
申请人 |
INDEX PHARMACEUTICALS AB |
发明人 |
ANDERSSON, PATRIK;KOUZNETSOV, NIKOLAI;POELLINGER, LORENZ;VON STEIN, PETRA |
分类号 |
G01N33/53;A01K67/027;A61K38/00;A61K38/55;A61K48/00;C07K14/435;C07K14/705;C12N15/85;C12Q;G01N33/566;G01N33/574 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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