A PROCESS FOR THE PREPARATION OF 4-AMINO-1-HYDROXYBUTYLIDENE-1,1-BISPHOSPHONIC ACID AND OF THE TRIHYDRATED MONOSODIUM SALT THEREOF

摘要

The invention relates to a process for the preparation of 4- amino-1-hydroxybutylidene-1,1-bisphosphonic acid and of the trihydrated monosodium salt thereof, consisting of reacting 4-aminobutyric acid with a phosphonation mixture formed by phosphorous acid and methanesulfonic anhydride and thereafter hydrolyzing the product of said reaction and isolating the products by adjustment of the pH.