PREPARATION FOR DETERMINING PYRIMIDINE METABOLIC CAPACITY

摘要

A method for measuring and evaluating the pyrimidine metabilizability of individual subjects on various fluorouracil-type chemicals typified by 5- fluorouracil which is decomposed in the pyrimidine metabolism pathway; and preparations which are useful in the measurement and evaluation as described above. The pyrimidine metabolizability in vivo can be evaluated by administering a preparation for measuring pyrimidine metabolizability containing a pyrimidine compound or a pyrimidine metabolite which is radio- labeled in at least one of carbon, oxygen and nitrogen atoms serving as the substrate in pyrimidine metabolic enzymes as the active ingredient, and then examining the metabolic behaviors based on the excretion.