发明名称 |
Compositions comprising human immunodeficiency virus Tat adsorbed to the surface of anionic nanoparticles |
摘要 |
Non-denatured, recombinant human immunodeficiency virus (HIV) Tat that is free of bacterial RNA and endotoxin is employed in an anti-HIV vaccine. A process of producing the recombinant Tat protein includes steps for removing bacterial RNA from the recombinant Tat and for removing endotoxin from the recombinant Tat protein. A Tat-adsorbed nanoparticle formulation and method of making the same. A method of vaccinating against and/or treating HIV infection comprises administering to a subject in need of such vaccination or treatment an immune-response inducing effective amount of the recombinant Tat protein.
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申请公布号 |
US7588764(B2) |
申请公布日期 |
2009.09.15 |
申请号 |
US20050506408 |
申请日期 |
2005.06.22 |
申请人 |
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION |
发明人 |
NATH AVINDRA;MUMPER RUSSELL J.;WOODWARD JEROLD;CUI ZHENGRONG |
分类号 |
A61K39/21;A61K39/385;A61K45/00;C07K14/16 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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