A class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These oligonucleotides have improved antisense properties. The oligonucleotides are composed of at least one LNA selected from beta-D-thio/amino-LNA or alpha-L-oxy/thio/amino-LNA. The oligonucleotides comprising LNA may also include DNA and/or RNA nucleotides.
申请公布号
AT442152(T)
申请公布日期
2009.09.15
申请号
AT20030773575T
申请日期
2003.11.18
申请人
SANTARIS PHARMA A/S
发明人
CHRISTENSEN, SIGNE M.;MIKKELSEN, NIKOLAJ DAM;FRIEDEN, MIRIAM;HANSEN, HENRIK FRYDENLUND;KOCH, TROELS;PEDERSEN, DANIEL SEJER;ROSENBOHM, CHRITOPH;THRUE, CHARLOTTE ALBAEK;WESTERGAARD, MAJKEN
