| 摘要 |
[PROBLEMS]To provide: a membrane integrity test method using a colloidal solution containing a metal particle or a metal compound particle, which can test on the integrity of a virus removal membrane comprising a hydrophilized synthetic polymer accurately after the filtration of a protein solution through the membrane; and a method for producing the colloidal solution.[MEANS FOR SOLVING PROBLEMS]An integrity test method for a microporous membrane, which comprises the step of filtering a colloidal solution comprising a solvent and a metal particle dispersed in the solvent through a microporous membrane, wherein the solvent comprises the components (A) and (B), the components (A) and (C), or the components (A), (B) and (C) mentioned below: (A) an anionic polymer having a sulfonate group, (B) at least one non-ionic surfactant selected from the group consisting of a non-ionic surfactant having a polycyclic structure in a hydrophobic moiety and an non-ionic surfactant of a polyoxyethylene sorbitan fatty acid ester; and (C) a water-soluble polymer having a pyrrolidone group. |
