发明名称 IN VIVO TEMPORAL CONTROL OF ACTIVATABLE MATRIX- DEGRADING ENZYMES
摘要 <p>Methods and combinations are provided for controlling the duration of action, in vivo, of matrix-degrading enzymes. The methods and combinations permit temporary in- vivo activation of matrix-degrading enzymes upon administration to the extra cellular matrix (or "ECM"). Matrix-degrading enzymes having a controlled duration of action can be used to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.</p>
申请公布号 CA2718549(A1) 申请公布日期 2009.09.11
申请号 CA20092718549 申请日期 2009.03.06
申请人 HALOZYME, INC. 发明人 KELLER, GILBERT A.;FROST, GREGORY I.
分类号 A61K38/48;A61P1/00;A61P17/02;A61P19/02 主分类号 A61K38/48
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