摘要 |
The invention relates to steroid-17, 17-lactol-derivatives with the chemical formula (I) and the tautomer forms thereof with general chemical formula (Ia) wherein R4, R6a, R6b, R7, R15, R16a, R16b, R18, R22and Z have the designations given in claim 1, and to the solvates, hydrates, stereoisomers and salts thereof. The invention also relates to the use of said derivatives for producing a medicament for oral contraception and for the treatment of premenopausal, perimenopausal and postmenopausal troubles, and medicaments containing said derivatives. The derivatives according to the invention have a gestagen effect, and in preferred cases, also an anti-mineral corticoid and neutral to lightly androgenous effect. |
申请人 |
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT;KLAR, ULRICH;KUHNKE, JOACHIM;BOHLMANN, ROLF;HUEBNER, JAN;RING, SVEN;FRENZEL, THOMAS;MENGES, FREDERIK;BORDEN, STEFFEN;MUHN, HANS, PETER;PRELLE, KATJA |
发明人 |
KLAR, ULRICH;KUHNKE, JOACHIM;BOHLMANN, ROLF;HUEBNER, JAN;RING, SVEN;FRENZEL, THOMAS;MENGES, FREDERIK;BORDEN, STEFFEN;MUHN, HANS, PETER;PRELLE, KATJA |