COMPOSITIONS AND METHODS FOR TREATING CHONDROSARCOMAS

摘要

Compositions, kits and methods for inhibiting growth of Chondrosarcoma cells involve compositions including PRP-I or PRP-I analogues in an amount effective to inhibit growth of the cells. A method of inhibiting growth of Chondrosarcoma cells includes providing a composition including PRP-I or a PRP-I analogue in an amount effective to inhibit growth of the Chondrosarcoma cells; and contacting the Chondrosarcoma cells with the composition, wherein contacting the Chondrosarcoma cells with the composition results in inhibition of growth of the Chondrosarcoma cells. A typical adjuvant composition includes PRP-I in an amount effective to inhibit growth of human Chondrosarcoma cells and a pharmaceutically acceptable carrier or diluent. Compositions and methods described herein are based on the discovery that contacting human Chondrosarcoma cells with PRP-l abolished MYC oncogene activity and inhibited growth of the Chondrosarcoma cells.