NOVEL FLAVONOL COMPOUNDS, A BIOACTIVE EXTRACT/FRACTION FROM ULMUS WALLICHIANA AND ITS COMPOUNDS FOR PREVENTION FOR TREATMENT OF OSTEO-HEALTH RELATED DISORDERS

摘要

The present invention provides a flavonol compound and a bioactive extract/fraction from Ulmus wallichiana useful for the management or prevention or treatment of bone disorders. Said extract/fraction comprising marker compounds of general formula 2, K058: R1=R2=OH K012: R1=R2=OH, 2,3 double bond K068: R1=R2=H KIOOi R1=OH, R2=H mula 2 Wherein the marker compounds K012, K058, K068, KlOO ranges 6.7 - 12%, 1.7- 4.5%, 0.6 - 1.2%, 1.7 - 4.5% respectively in alcoholic extract and a process of extraction thereof. According to another aspect of the invention provides a pharmaceutical composition comprising the said compound. The present invention further provides a method of treating bone disorders by administering the pharmaceutical composition by oral, intravenous, subcutaneous, intra-peritoneal or intramuscular route.