A METHOD FOR EVALUATING OR SELECTING AGENTS HAVING PREVENTIVE OR ALLEVIATIVE EFFECTS ON SPOTS

摘要

The object of the present invention is to provide a method for evaluating or selecting an agent having preventive or alleviative effects on spots, which method realizes reliable and effective screening of candidate substances of the agent; a method for predicting spot formation; and a method for analyzing the condition of skin spots. The method of the present invention for evaluating or selecting an agent having preventive or alleviative effects on spots, includes evaluating a substance which suppresses a p53 activity, or an expression level of a p53 gene, a p53 target gene or an expression product thereof in an epidermal cell.