SUBSTRATE FOR PATCH-CLAMP DEVICE, PLANAR SUBSTRATE TYPE PATCH-CLAMP DEVICE, AND METHOD OF MEASURING CELL ION CHANNEL ACTIVITY

摘要

PROBLEM TO BE SOLVED: To provide a planar substrate type patch-clamp device technology which can easily downsize a device and allows simple use, and moreover enables high sensitive and accurate measurement.

SOLUTION: The substrate for the patch-clamp device is an electric insulating substrate in which an aperture on one side in a through-hole connecting both surface sides of the substrate has a bore diameter smaller than that of a cell and an extracellular matrix formative substance is provided on the circumference of the aperture. The planar substrate type patch-clamp device is provided with: liquid reservoirs for holding conductive liquid on the both surface sides of the through-hole of the substrate; and electrodes disposed for energizing the conductive liquid.

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