发明名称 |
METHODS AND MATERIALS RELATING TO ENHANCED PRODUCTION OF DOPAMINE NEURONS |
摘要 |
Induction of neuronal fate in neural stem cells or neural progenitor or precursor cells, or other stem cells, and enhancement of induction of a specific neuronal phenotype, and particularly to induction and enhancement of induction of a midbrain dopaminergic neuronal phenotype. Expressing a nuclear receptor of the Nurr1 subfamily above basal levels within the cell, and regulating GSK-3beta inhibition within the cell other than by means of a ligand for a Frizzled receptor.
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申请公布号 |
US2009226536(A1) |
申请公布日期 |
2009.09.10 |
申请号 |
US20050574606 |
申请日期 |
2005.09.02 |
申请人 |
ARENAS ERNESTO A;CASTELO BRANCO GONCALO;RAWAL NINA |
发明人 |
ARENAS ERNESTO A.;CASTELO BRANCO GONCALO;RAWAL NINA |
分类号 |
A61K35/30;A61K35/12;A61P25/16;C12N5/0793;C12Q1/02;C12Q1/68 |
主分类号 |
A61K35/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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