| 发明名称 |
CRYSTALLINE FORMS OF (R)-8-CHLORO-1-METHYL- 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE |
| 摘要 |
The present invention is directed to methods of preparing ( R )-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride hemihydrate comprising at least partially dissolving ( R )-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride in a crystallizing solvent containing water, and inducing precipitation of the hemihydrate from the crystallizing solvent. |
| 申请公布号 |
EP1838677(B1) |
申请公布日期 |
2009.09.09 |
| 申请号 |
EP20050855526 |
申请日期 |
2005.12.20 |
| 申请人 |
ARENA PHARMACEUTICALS, INC. |
发明人 |
AGARWAL, RAJESH KUMAR;BETTS, III, WILLIAM L.;HENSHILWOOD, JAMES A.;KIANG, YUAN-HON;POST, NOAH |
| 分类号 |
C07D223/16;A61K31/55;A61P3/04;A61P25/24;A61P25/30 |
主分类号 |
C07D223/16 |
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