发明名称 |
Esters of glucuronide prodrugs of anthracyclines and method of preparation and use in tumor-selective chemotherapy |
摘要 |
The invention relates to novel esters and in particular to novel water soluble esters of glucuronide prodrugs of anthracyclines their synthesis and use in tumor-selective chemotherapy. It appeared that in the final step in the synthesis of these prodrugs, i.e. the coupling of the glucuronide spacer moiety to the parent drug molecule, protection of the sugar hydroxyls is, surprisingly, no longer required. A process for the preparation of these unprotected sugar spacer moieties is also disclosed.
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申请公布号 |
EP2098533(A1) |
申请公布日期 |
2009.09.09 |
申请号 |
EP20080004249 |
申请日期 |
2008.03.07 |
申请人 |
PHARMACHEMIE B.V. |
发明人 |
ABEN, RENE WILHELMUS MARIE;SCHEEREN, JOHAN WILHELM;CORNELISSEN, JEROEN JOHANNES, LAMBERUTS, MARIA;DE VOS, DICK;HAISMA, HIDDE JACOB |
分类号 |
A61K31/704;C07H15/252;A61P35/00 |
主分类号 |
A61K31/704 |
代理机构 |
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