发明名称 |
SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS |
摘要 |
<p>The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also realtes to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.</p> |
申请公布号 |
EP1373285(A4) |
申请公布日期 |
2009.09.09 |
申请号 |
EP20020725551 |
申请日期 |
2002.04.02 |
申请人 |
GENENCOR INTERNATIONAL, INC.;THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO |
发明人 |
DAVIS, BENJAMIN, G.;JONES, JOHN, BRYAN;BOTT, RICHARD, R. |
分类号 |
A61K47/48;C07H5/10;C07K14/36;C12N1/21;(IPC1-7):C07H1/00;C07H17/00;A61K31/70;A61K38/16 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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