发明名称 |
Protein kinase C zeta inhibition to treat vascular permeability |
摘要 |
Methods of treating or preventing a disease or disorder in a subject are provided by the present invention which include administering a composition including a therapeutically effective amount of a protein kinase C (PKC) zeta inhibitor. A disease or disorder treated or prevented by administration of a PKC zeta inhibitor is characterized by abnormal vascular permeability. Diseases or disorders treated or prevented by administration of a composition including a therapeutically effective amount of a PKC zeta inhibitor include cancer, an ischemic condition and microvascular complications of a systemic or local condition in the subject, such as diabetes and/or diabetic macular edema. Additionally, methods of inhibiting PKC zeta are provided which include incubating PKC zeta in vivo, in vitro and/or in silico with a PKC zeta inhibitor.
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申请公布号 |
US7585865(B2) |
申请公布日期 |
2009.09.08 |
申请号 |
US20070781498 |
申请日期 |
2007.07.23 |
申请人 |
THE PENN STATE RESEARCH FOUNDATION |
发明人 |
ANTONETTI DAVID A.;SUNDSTROM JEFFREY M.;SMITH CHARLES D. |
分类号 |
A61K31/497;A61K31/35;A61K31/38 |
主分类号 |
A61K31/497 |
代理机构 |
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地址 |
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