发明名称 |
Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof |
摘要 |
Disclosed are hydrophilic choline/N-heterocycle ester compounds containing single amino acids, peptides, or derivatives thereof which have the potential to express anti-oxidant activity capable of reducing reactive oxygen species in cells. These compounds may be used to inhibit oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.
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申请公布号 |
US7585846(B2) |
申请公布日期 |
2009.09.08 |
申请号 |
US20040580803 |
申请日期 |
2004.11.26 |
申请人 |
UNIVERSITY OF ROCHESTER |
发明人 |
SHEU SHEY-SHING;ANDERS MARION W.;XU LIN;SHARMA VIRENDRA K. |
分类号 |
A61K31/24;A61K31/519;A61K31/724;C07C205/00;C07C229/00;C07C261/00;C07C269/00;C07C271/00;C07K;C07K5/02 |
主分类号 |
A61K31/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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