发明名称 |
A RECOMBINANT MOUSE-HUMAN CHIMERIC FAB AGAINST HEPATITIS B SURFACE ANTIGEN |
摘要 |
<p>This invention relates to a recombinant chimeric Fab antibody comprising a recombinant Fd and a recombinant chimeric light chain which binds to hepatitis B surface antigen with high affinity, generated by fusing variable region genes (VH and VL) of an anti-HBsAg mouse antibody 5S and constant region genes of human, CH1 region of human IgGI and the CL region of human kappa chain, wherein mouse VL and human CL are linked by overlap PCR to generate chimeric light chain and mouse VH and CH1 are linked by overlap PCR to generate chimeric Fd.</p> |
申请公布号 |
KR20090094850(A) |
申请公布日期 |
2009.09.08 |
申请号 |
KR20097015239 |
申请日期 |
2007.09.10 |
申请人 |
DEPARTMENT OF BIOTECHNOLOGY;ALL INDIA INSTITUTE OF MEDICAL SCIENCES;INTERNATIONAL CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY |
发明人 |
BOSE BIPLAB;SINHA SUBURATA;KHANNA NAVIN;ACHARYA SUBRAT KUMAR |
分类号 |
C07K16/46;A61K39/395;C07K14/02 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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