发明名称 |
TOPOISOMERASE II POISON AND BIS-DIOXYPIPERAZINE DERIVATIVE COMBINATION THERAPY |
摘要 |
The present invention relates to a method for selectively killing tumour or metastatic cells within a defined compartment of the organism of a large mammal, in particular a human, said method comprising administering to a mammal an effective tumour- or metastasis-killing amount of a topoisomerase II poison except doxorubicin, and protecting non- tumourous tissue of the mammal against the toxic action of the topoisomerase II poison by administration of a bis-dioxypiperazine compound. In particular, the invention relates to a pharmaceutical kit for selectively killing tumour or metastatic cells within the central nervous system of a large mammal, in particular a human, said kit comprising: a) a dosage unit of a bis-dioxypiperazine and a pharmaceutically acceptable carrier, and b) a dosage unit of topoisomerase II poisons except doxorubicin and a pharmaceutically acceptable carrier.</SDOAB >
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申请公布号 |
CA2242406(C) |
申请公布日期 |
2009.09.08 |
申请号 |
CA19972242406 |
申请日期 |
1997.01.10 |
申请人 |
SEHESTED, MAXWELL;JENSEN, PETER BUHL |
发明人 |
SEHESTED, MAXWELL;JENSEN, PETER BUHL |
分类号 |
A61K31/495;A61K31/47;A61K31/70;A61K45/06 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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