发明名称 PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND USE THEREOF FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF mGluR5 RECEPTOR MEDIATED DISORDERS
摘要 This invention relates to a compound and the use of the compound of the formula wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4 </SUP>and R<SUP>5 </SUP>are as defined in the description, A signifies -CH-CH- or -C≡C-; and B signifies wherein R<SUP>6 </SUP>to R<SUP>26</SUP>, X and Y are as defined in the specification or a pharmaceutically acceptable salt thereof, for use in pharmaceutical compositions for the treatment or prevention of mGluR5 receptor mediated disorders.
申请公布号 IL155999(A) 申请公布日期 2009.09.01
申请号 IL20030155999 申请日期 2003.05.19
申请人 F. HOFFMANN-LA ROCHE AG 发明人
分类号 C07D233/64;A61K31/4045;A61K31/415;A61K31/4164;A61K31/4174;A61K31/4178;A61K31/4245;A61K31/437;A61K31/4985;A61P1/08;A61P9/02;A61P9/10;A61P13/02;A61P21/02;A61P25/00;A61P25/04;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/34;A61P25/36;A61P31/18;A61P43/00;C07D209/14;C07D209/16;C07D231/12;C07D233/54;C07D233/58;C07D233/68;C07D233/90;C07D233/92;C07D233/94;C07D403/06;C07D403/10;C07D413/04;C07D491/147;C07D495/14;C07D498/04;C07D513/14 主分类号 C07D233/64
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