发明名称 |
Nadph oxidase cytosolic cofactor mutant |
摘要 |
A purified polypeptide includes an NADPH oxidase cytosolic cofactor polypeptide NOXA1 or p67phox having a C-terminal SH3 domain insertion mutation of at least three consecutive amino acids positioned between PEDL (SEQ ID NO: 35) and GIFPK (SEQ ID NO: 34) motifs of said SH3 domain so as to reduce activity of the purified polypeptide relative to the wild-type cofactor polypeptide. A process for treating, inhibiting, or prophylactically preventing a disease associated with the overproduction of reactive oxygen species involving NOXn where n is 1-4 inclusive includes the administration of a therapeutically effective amount with a purified polypeptide to a subject tissue that is overproducing reactive oxygen species through a NOXn pathway.
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申请公布号 |
US7582606(B2) |
申请公布日期 |
2009.09.01 |
申请号 |
US20060556314 |
申请日期 |
2006.11.03 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
VALENTE ANTHONY J.;CLARK ROBERT A. |
分类号 |
A61K38/00;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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