发明名称 |
Anti-idiotypic antibodies against factor VIII inhibitor and uses thereof |
摘要 |
The present invention discloses anti-idiotypic antibodies and fragments thereof against inhibitory Factor VIII anti-bodies, said inhibitory antibodies having an affinity for the C2 domain of Factor VIII. The anti-idiotypic antibodies of the present invention are able to completely neutralise in vitro and in an in vivo mouse model the inhibitory activity of FVIII inhibitors. The anti idiotypic antibodies of the present invention can be applied for the prevention, treatment or reduction of bleeding disorders of hemophilia patients with inhibitory antibody against the C2 domain of Factor VIII.
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申请公布号 |
US7582296(B2) |
申请公布日期 |
2009.09.01 |
申请号 |
US20050523444 |
申请日期 |
2005.01.31 |
申请人 |
D. COLLEN RESEARCH FOUNDATION VZW |
发明人 |
GILLES JEAN GUY G.;SAINT-REMY JEAN-MARIE R.;JACQUEMIN MARC G. |
分类号 |
A61K39/395;A61K38/08;A61K38/17;C07K14/705;C07K16/42;C12N5/16 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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