发明名称 |
Diagnostic assay for Wiskott-Aldrich syndrome and genetically related disorders |
摘要 |
The methods and compositions of the invention find use in the clinical diagnosis of primary immunodeficiencies, particularly Wiskott-Aldrich related syndromes. The compositions of the invention include isolated nucleic acid molecules and oligonucleotide pairs suitable for use in amplifying regions of the Wiskott-Aldrich syndrome protein gene and in determining the nucleotide sequence of the Wiskott-Aldrich syndrome protein gene in a patient. The invention facilitates efficient, cost-effective amplification of one or more regions of the Wiskott-Aldrich syndrome protein gene. The nucleotide sequence of amplified DNA comprising one or more regions of the Wiskott-Aldrich Syndrome Protein gene can be determined using the methods and compositions of the invention. Knowledge of the patient's nucleotide sequence in the Wiskott-Aldrich Syndrome Protein gene allows diagnosis of the patient's primary immunodeficiency.
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申请公布号 |
US7582738(B2) |
申请公布日期 |
2009.09.01 |
申请号 |
US20050295149 |
申请日期 |
2005.12.06 |
申请人 |
CHILDREN'S HOSPITAL MEDICAL CENTER |
发明人 |
ZHANG KEJIAN;WENSTRUP RICHARD J.;FILIPOVICH ALEXANDRA H. |
分类号 |
C07H19/00;C07H21/04;C12P19/34;C12Q1/68 |
主分类号 |
C07H19/00 |
代理机构 |
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