DERIVATIVES OF 3-(GUANIDINOCARBONYL) HETEROCYCLE, METHODS OF PREPARATION AND INTERMEDIATES THEREOF, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS THEREFROM

摘要

THE PRESENT INVENTION DISCLOSES AND CLAIMS COMPOUNDS OF FORMULA I AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, AND METHODS OF USING SAID COMPOUNDS OF FORMULA I, EITHER ALONE OR IN COMBINATION WITH OTHER MEDICAMENTS, AS ANTIARRHYTHMIC MEDICAMENTS WITH A CARDIOPROTECTIVE COMPONENT FOR PROPHYLAXIS OR TREATMENT OF INFARCTION, FOR THE TREATMENT OF ANGINA PECTORIS, AND AS INHIBITORS OF PATHOPHYSIOLOGICAL PROCESSES ASSOCIATED WITH THE DEVELOPMENT OF ISCHEMIA-INDUCED DAMAGE, IN PARTICULAR IN THE TRIGGERING OF ISCHEMIA-INDUCED CARDIAC ARRHYTHMIAS AND OF HEART FAILURE. PHARMACEUTICAL COMPOSITIONS COMPRISING COMPOUNDS OF FORMULA I OR COMPOUNDS OF FORMULA I IN COMBINATION WITH ONE OR MORE OTHER MEDICAMENTS AND PROCESSES FOR THE PREPARATION OF COMPOUNDS OF FORMULA I ARE ALSO DISCLOSED AND CLAIMED.