| 摘要 |
Disclosed is the use of an artemin of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO: 5, and artemin variants thereof having at least 85% amino acid sequence identity with SEQ ID NOs: 1,3 or 5, in the manufacture of a medicament for protecting neurons in a mammal from injury-induced pathological changes without accompanying mechanical or thermal hyperalgesia, for administration in the dose range of between about 0.01 microgram/kg and about 1 mg/kg, wherein said injury is selected from an injury associated with trauma, a toxic agent, adverse side effects of other therapeutic agents, surgery, stroke, ischemia, infection, metabolic disease, nutritional deficiency, malignancy, a neurodegenerative disease, and a neuropathy.
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